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DC Field | Value | Language |
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dc.contributor.advisor1 | Hattori, Renata Takeara | - |
dc.contributor.advisor1Lattes | http://lattes.cnpq.br/0659464190667878 | pt_BR |
dc.contributor.referee1 | Corrêa, Geone Maia | - |
dc.contributor.referee1Lattes | http://lattes.cnpq.br/7274488066461409 | pt_BR |
dc.contributor.referee2 | Ávila, Maiara de Souza Nunes | - |
dc.contributor.referee2Lattes | http://lattes.cnpq.br/3586108544908670 | pt_BR |
dc.creator | Queiroz, César Castelo Branco de | - |
dc.creator.Lattes | http://lattes.cnpq.br/4910312424146742 | pt_BR |
dc.date.accessioned | 2021-07-21T13:38:56Z | - |
dc.date.available | 2021-07-14 | - |
dc.date.available | 2021-07-21T13:38:56Z | - |
dc.identifier.uri | http://riu.ufam.edu.br/handle/prefix/5916 | - |
dc.description.abstract | The Piper callosum species is one of the more than 3,700 species belonging to the Piperaceae family, being popularly known as “electric oil. Its leaves and stalks are used in the form of tea to treat dysentery, nausea, dysmenorrhea, rheumatic and muscle pain, and as a natural repellent. These effects can be attributed to substances present in its leaf extracts, belonging to the classes of amides, steroids and alkaloids. Therefore, the objective of this work was to evaluate the chemical composition of the essential oil, crude extract and fractions of Piper callosum and to evaluate the antimicrobial activity against the microorganisms Escherichia coli, Staphylococcus aureus, Candida albicans and Candida parapsilosis. The extract was fractionated by liquid-liquid partition with hexane, chloroform, ethyl acetate and butanol. Essential oils were obtained by hydrodistillation of fresh material in a Clevenger apparatus. The chemical profile of crude extract and fractions was analyzed through chromatic reactions in tubes and thin-layer chromatography. The determination of chemical constituents of essential oils was carried out through gas chromatography analysis coupled with mass spectrometry. The crude extract, fractions and essential oils were submitted to the antimicrobial activity test. The yields of the crude extract, hexane, chloroform, ethyl acetate, butanol and hydroalcoholic fraction were respectively 19.22%, 15.13%, 1.64%, 1.45%, 10.41% and 71.35%. Three fractions of essential oils were obtained, with yields of 0.36% in OE1 (densest), 0.17% in OE2 (less dense) and 0.27% in OE3 (intermediate density). The classes of metabolites detected in thin-layer chromatography and confirmed through phytochemical surveys were steroids, saponins and phenolic compounds. The essential oil presented as major compounds safrole (74.24%), α-pinene, β-pinene and 1,8-cineole, demonstrating antimicrobial activity against all microorganisms studied. Further studies are needed to determine the minimum inhibitory concentration and confirm which isolated substance is responsible for this antimicrobial action. | pt_BR |
dc.description.resumo | A espécie Piper callosum é uma das mais de 3.700 espécies integrantes da Família Piperaceae, sendo popularmente conhecida como “óleo elétrico”. Suas folhas e talos são usados sob a forma de chá para tratar disenteria, náusea, dismenorreia, dores reumáticas e musculares e como repelente natural. Tais efeitos podem ser atribuídos às substâncias presentes nos extratos de suas folhas, pertencentes às classes das amidas, esteroides e alcaloides. Sendo assim, o objetivo deste trabalho foi avaliar a composição química do óleo essencial, extrato bruto e frações de Piper callosum e avaliar a atividade antimicrobiana frente aos microrganismos Escherichia coli, Staphylococcus aureus, Candida albicans e Candida parapsilosis. As folhas foram coletadas no Campus do ICET e extraídas com etanol 70% sob refluxo. O extrato foi fracionado por partição líquido-líquido com hexano, clorofórmio, acetato de etila e butanol. Os óleos essenciais foram obtidos por hidrodestilação do material fresco em aparelho de Clevenger. O perfil químico do extrato bruto e das frações foi analisado através de reações cromáticas em tubos e cromatografia em camada fina. A determinação dos constituintes químicos dos óleos essenciais foi realizada através da análise por cromatografia gasosa acoplada a espectrometria de massas. O extrato bruto, frações e óleos essenciais foram submetidos ao ensaio de atividade antimicrobiana. Os rendimentos para o extrato bruto, fração hexânica, clorofórmica, acetato de etila, butanol e hidroalcoólica foram, respectivamente 19,22%, 15,13%, 1,64%, 1,45%, 10,41% e 71,35%. Foram obtidas três frações dos óleos essenciais, com rendimentos de 0,36% em OE1 (mais denso), 0,17% em OE2 (menos denso) e 0,27% em OE3 (densidade intermediária). As classes de metabólitos detectadas em cromatografia em camada fina e confirmadas através de prospecções fitoquímicas foram esteroides, saponinas e compostos fenólicos. O óleo essencial apresentou como compostos majoritários safrol (74,24%), α-pineno, β-pineno e 1,8-cineol, demonstrando atividade antimicrobiana frente aos microrganismos estudados. São necessários mais estudos para se determinar a concentração inibitória mínima e confirmar qual substância isolada é responsável por essa ação antimicrobiana. | pt_BR |
dc.language | por | pt_BR |
dc.publisher.country | Brasil | pt_BR |
dc.publisher.department | Instituto de Ciências Exatas e Tecnologia - ICET | pt_BR |
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dc.rights | Acesso Aberto | pt_BR |
dc.subject | Piper callosum | pt_BR |
dc.subject | Piperaceae | pt_BR |
dc.subject | Óleos essenciais | pt_BR |
dc.subject | Extrato | pt_BR |
dc.subject | Atividade Antimicrobiana | pt_BR |
dc.subject.cnpq | CIÊNCIAS DA SAÚDE: FARMÁCIA | pt_BR |
dc.title | Caracterização química e atividade antimicrobiana do óleo essencial, extrato bruto e frações de Piper callosum Ruiz & Pav. (Piperaceae) | pt_BR |
dc.type | Trabalho de Conclusão de Curso | pt_BR |
dc.creator.affiliation | Universidade Federal do Amazonas | pt_BR |
dc.date.event | 2021-06-17 | - |
dc.publisher.localpub | Itacoatiara/AM | pt_BR |
dc.subject.controlado | Óleo elétrico | pt_BR |
dc.subject.controlado | Ação antimicrobiana | pt_BR |
dc.subject.controlado | Repelente natural | pt_BR |
dc.subject.controlado | Essências e óleos essenciais | pt_BR |
dc.creator.orcid | 4910312424146742 | pt_BR |
dc.contributor.advisor1orcid | https://orcid.org/0000-0003-1052-1822 | pt_BR |
dc.contributor.advisor1orcid | https://orcid.org/0000-0003-1052-1822 | pt_BR |
dc.contributor.referee1orcid | https://orcid.org/0000-0002-9458-8305 | pt_BR |
dc.contributor.referee1orcid | https://orcid.org/0000-0002-9458-8305 | pt_BR |
dc.contributor.referee2orcid | https://orcid.org/0000-0002-9744-3283 | pt_BR |
dc.creator.affiliation-init | UFAM | pt_BR |
dc.publisher.course | Farmácia - Bacharelado - Itacoatiara | pt_BR |
Appears in Collections: | Trabalho de Conclusão de Curso - Graduação - Ciências da Saúde |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
TCC_CésarQueiroz.pdf | Farmácia - Bacharelado - Itacoatiara | 2,3 MB | Adobe PDF | View/Open |
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