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dc.contributor.advisor1Hattori, Renata Takeara-
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/0659464190667878pt_BR
dc.contributor.referee1Corrêa, Geone Maia-
dc.contributor.referee1Latteshttp://lattes.cnpq.br/7274488066461409pt_BR
dc.contributor.referee2Ávila, Maiara de Souza Nunes-
dc.contributor.referee2Latteshttp://lattes.cnpq.br/3586108544908670pt_BR
dc.creatorQueiroz, César Castelo Branco de-
dc.creator.Latteshttp://lattes.cnpq.br/4910312424146742pt_BR
dc.date.accessioned2021-07-21T13:38:56Z-
dc.date.available2021-07-14-
dc.date.available2021-07-21T13:38:56Z-
dc.identifier.urihttp://riu.ufam.edu.br/handle/prefix/5916-
dc.description.abstractThe Piper callosum species is one of the more than 3,700 species belonging to the Piperaceae family, being popularly known as “electric oil. Its leaves and stalks are used in the form of tea to treat dysentery, nausea, dysmenorrhea, rheumatic and muscle pain, and as a natural repellent. These effects can be attributed to substances present in its leaf extracts, belonging to the classes of amides, steroids and alkaloids. Therefore, the objective of this work was to evaluate the chemical composition of the essential oil, crude extract and fractions of Piper callosum and to evaluate the antimicrobial activity against the microorganisms Escherichia coli, Staphylococcus aureus, Candida albicans and Candida parapsilosis. The extract was fractionated by liquid-liquid partition with hexane, chloroform, ethyl acetate and butanol. Essential oils were obtained by hydrodistillation of fresh material in a Clevenger apparatus. The chemical profile of crude extract and fractions was analyzed through chromatic reactions in tubes and thin-layer chromatography. The determination of chemical constituents of essential oils was carried out through gas chromatography analysis coupled with mass spectrometry. The crude extract, fractions and essential oils were submitted to the antimicrobial activity test. The yields of the crude extract, hexane, chloroform, ethyl acetate, butanol and hydroalcoholic fraction were respectively 19.22%, 15.13%, 1.64%, 1.45%, 10.41% and 71.35%. Three fractions of essential oils were obtained, with yields of 0.36% in OE1 (densest), 0.17% in OE2 (less dense) and 0.27% in OE3 (intermediate density). The classes of metabolites detected in thin-layer chromatography and confirmed through phytochemical surveys were steroids, saponins and phenolic compounds. The essential oil presented as major compounds safrole (74.24%), α-pinene, β-pinene and 1,8-cineole, demonstrating antimicrobial activity against all microorganisms studied. Further studies are needed to determine the minimum inhibitory concentration and confirm which isolated substance is responsible for this antimicrobial action.pt_BR
dc.description.resumoA espécie Piper callosum é uma das mais de 3.700 espécies integrantes da Família Piperaceae, sendo popularmente conhecida como “óleo elétrico”. Suas folhas e talos são usados sob a forma de chá para tratar disenteria, náusea, dismenorreia, dores reumáticas e musculares e como repelente natural. Tais efeitos podem ser atribuídos às substâncias presentes nos extratos de suas folhas, pertencentes às classes das amidas, esteroides e alcaloides. Sendo assim, o objetivo deste trabalho foi avaliar a composição química do óleo essencial, extrato bruto e frações de Piper callosum e avaliar a atividade antimicrobiana frente aos microrganismos Escherichia coli, Staphylococcus aureus, Candida albicans e Candida parapsilosis. As folhas foram coletadas no Campus do ICET e extraídas com etanol 70% sob refluxo. O extrato foi fracionado por partição líquido-líquido com hexano, clorofórmio, acetato de etila e butanol. Os óleos essenciais foram obtidos por hidrodestilação do material fresco em aparelho de Clevenger. O perfil químico do extrato bruto e das frações foi analisado através de reações cromáticas em tubos e cromatografia em camada fina. A determinação dos constituintes químicos dos óleos essenciais foi realizada através da análise por cromatografia gasosa acoplada a espectrometria de massas. O extrato bruto, frações e óleos essenciais foram submetidos ao ensaio de atividade antimicrobiana. Os rendimentos para o extrato bruto, fração hexânica, clorofórmica, acetato de etila, butanol e hidroalcoólica foram, respectivamente 19,22%, 15,13%, 1,64%, 1,45%, 10,41% e 71,35%. Foram obtidas três frações dos óleos essenciais, com rendimentos de 0,36% em OE1 (mais denso), 0,17% em OE2 (menos denso) e 0,27% em OE3 (densidade intermediária). As classes de metabólitos detectadas em cromatografia em camada fina e confirmadas através de prospecções fitoquímicas foram esteroides, saponinas e compostos fenólicos. O óleo essencial apresentou como compostos majoritários safrol (74,24%), α-pineno, β-pineno e 1,8-cineol, demonstrando atividade antimicrobiana frente aos microrganismos estudados. São necessários mais estudos para se determinar a concentração inibitória mínima e confirmar qual substância isolada é responsável por essa ação antimicrobiana.pt_BR
dc.languageporpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentInstituto de Ciências Exatas e Tecnologia - ICETpt_BR
dc.relation.referencesAFILAL, M. E.; OUAHID, E.; BEREBAH, M.; EL FARH, L. Valuation of aromatic and medicinal plants (AMP) of Rif (Northern Morocco). Der Pharma Chemica, v. 8, p. 439-445, 2016. AL-MADHAGI, W. M.; HASHIM, N. M.; ALI, N. A. A.; ALHADI, A. A.; HALIM, S. N. A.; OTHMAN, R. Chemical profiling and biological activity of Peperomia blanda (Jacq.) Kunth. PeerJ, v. 6, p. 1-19, 2018. AMARATHUNGA, A. A. M. D. D. N.; KANKANAMGE. A review on pharmacognostic, phytochemical and ethnopharmacological findings of Peperomia pellucida (L.) Kunth: Pepper Elder. International Research Journal of Pharmacy, v. 8, p. 16-23, 2017. AMMAR, S.; NOUI, H.; DJAMEL, S.; MADANI, S.; MAGGI, F.; BRUNO, M.; ROMANO, D.; CANALE, A.; PAVELA, R.; BENELLI, G. Essential oils from three Algerian medicinal plants (Artemisia campestris, Pulicaria Arabica, and Saccocalyx satureioides) as new botanical inseticides?. Environmental Science and Poluition Research, v. 2020, p. 1-11, 2020. ANDRADE, L.N.; SIQUEIRA, T.E.S.; MARTINEZ, R.; DARINI, A. L. C. Multidrug- Resistant CTX-M-(15,9,2-Producing Enterobacter hormaechei and Enterobacter asburiae Isolates Possessed a Set of Acquired Heavy Metal Tolerance Genes Includinga Chromosonal sil Operon (for Acquired Silver Resistance). Frontiers in Microbiology, v. 9, p. 1-6, 2018. AWORH, M. K.; KWAGA, J.; OKOLOCHA, E.; MBA, N.; THAKUR, S. Prevalence and risk factors for multi-drug resistant Escherichia coli among poultry workers in the Federal Capital Territory, Abuja, Nigeria. Plos One, v. 14, p. 1-15, 2019. BALDIN, E. L. L.; FANELA, T. L. M.; PANNUTI, L. F. R.; KATO, M. J.; TAKEARA, R.; CROTTI, A. E. M. Botanical extracts: alternative control for silverleaf whitefly management in tomato. Horticultura Brasileira, v. 33, p. 59-65, 2015. BARBOSA, Q. P. S.; CÂMARA, C. A. G.; RAMOS, C. S.; NASCIMENTO, D. C. O.; LIMA-FILHO, J. V. Chemical composition, circadian rhythm and antibacterial activity of essential oils of Piper divaricatum: A new source of safrole. Química Nova, v. 35, p. 1806-1808, 2012. BRAGA, A. G. S.; SOUZA, K. F. A.; BARBIERI, F. S.; FERNANDES, C. F.; ROCHA, R. B.; VIEIRA JUNIOR, J. R.; LACERDA, C. L.; CELESTINO, C. O.; FACUNDO, V. A.; BRITO, L. G. Acaricidal activity of extracts from different structures of Piper tuberculatum against larvae and adults of Rhipicephalus microplus. Acta Amazonica, v. 48, p. 57-62, 2018. 40 BRASIL, 2019. Resistência antimicrobiana é ameaça global, diz OMS. Portal ANVISA. Notícias. Disponível em: http://portal.anvisa.gov.br/noticias. Acesso em: 26 de maio de 2020. CALIXTO, J. B. The role of natural products in modern drug discovery. Anais da Academia Brasileira de Ciências, v. 91, p. 1-7, 2019. CARNEIRO, J. N. P.; CRUZ, R. P.; SILVA, J. C. P.; ROCHA, J. E.; FREITAS, T. S.; SALES, D. L.; BEZERRA, C. F.; ALMEIDA, W. O.; COSTA, J. G. M.; SILVA, L. E.; AMARAL, W.; REBELO, R. A.; BEGNINI, I. M.; COUTINHO, H. D. M.; MORAIS- BRAGA, M. F. B. Piper diospyrifolium Kunth.: Chemical analysis and antimicrobial (intrinsic and combined) acivities. Microbial Pathogenesis, v. 136, p. 1-9, 2019. CARVALHO-SILVA, M.; GUIMARÃES, E. F.; MEDEIROS E. V. S. Flora da Serra do Cipó, Minas Gerais: Piperaceae. Boletim de Botânica da Universidade de São Paulo v. 3, p. 27-40, 2013. CHANPRAPAI, P.; CHAVASIRI, W. Antimicrobial activity from Piper sarmentosum Roxb. Against rice pathogenic bacteria and fungi. Journal of Integrative Agriculture, v. 16, p. 2513-2524, 2017. CHEN, D. Q.; HU, H. H.; WANG, Y. N.; FENG, Y. L.; CAO, G.; ZHAO, Y. Y. Natural products for the prevention and treatment of kidney disease. Phytomedicine, v. 50, p. 50-60, 2018. CHRISTENHUS, M. J. M.; BYNG, J. W. The number of known plants species in the world and its annual increase. Phytotaxa, v. 261, p. 201-217, 2016. CRUZ, S. M.; CÁCERES, A.; ÁLVARES, L. E.; APEL, M. A.; HENRIQUES, A. T. Chemical diversity of essential oils of 15 Piper species from Guatemala. Acta Horticulturae, v. 964, p. 39-46, 2012. DIAS, P. A.; MORAES, T. P.; WILSMANN, D. E.; FERRASSO, M. M.; MARINHEIRO, M. F.; HEINEN, J. G.; CLABUIG, C. I. P.; TIMM, C. D. Ocorrência de Campylobacter e Enterobacteriaceae em aves silvestres e frangos de corte. Arquivos Brasileiros de Medicina Veterinária, v. 71, p. 225-231, 2019. DORLA, E.; GAUVIN-BIALECKI, DEUSCHER, Z.; ALLIBERT, A.; GRONDIN, I.; DEGUINE, J. P.; LAURENT, P. Insecticidal Activity of the Leaf Essential Oil of Peperomia borbonensis Miq. (Piperaceae) and Its Major Components against the Melon Fly Bactrocera cucurbitae (Diptera: Tephritidae). Chemistry & Biodiversity, v. 14, p. 1-9, 2017. EJELE, A. E.; DURU, I. A.; OGUKWE, C. E.; IWU, I. C. Phytochemistry and antimicrobial potential of basic metabolities of Piper umbellatum, Piper guineense, Ocimun gratissimium and Newbouldia laevis extracts. Journal of Emerging Trends in Engineering and Applied Sciences, v. 3, p. 309-314, 2012. EGWU-IKECHUKWU, M. M.; OGBU, O.; UZOH, C. V.; UDE, I. U.; BRAIDE, W.; ADELEYE, S. A. Antibacterial properties of selected medicinal plants on E. coli, 41 Salmonella sp and Shigella sp. International Journal of Pharmaceutical Sciences Review and Research, v. 49, p. 120-127, 2018. ELTZOV, E.; PENNYBAKER, S.; SHANIT-ORLAND, M.; MARKS, R. S.; KUSHMARO, A. Multi-resistance as a tool for detecting novel beta-lactam antibiotics in the environment Sensor Actuat B-Chem, v. 174, p. 342-8, 2012. FARIAS, P. K. S.; SILVA, J. C. R. L.; SPUZA, C. N.; FONSECA, F. S. A.; BRANDI, I. V.; MARTINS, E. R.; AZEVEDO, A. M.; ALMEIDA, A. C. Antioxidant activity of essential oils from condiment plants and their effect on lactic cultures and pathogenic bacteria. Ciência Rural, v. 49, p. 1-12, 2019. FLAMINI, G. Acaricides of natural origin, personal experiences and review of literature (1990- 2001). Studies in Natural Products Chemistry 2 381-451, 2003. FLORES, N.; TICONA, J. C.; BILBAO-RAMOS, P.; DEA-AYUELA, M. A.; MACEDO, J. C. R.; BAZZOCCHI, I. L. An unprecedented chloride-containing piperamide from Piper pseudoarboreum a potential leishmanicidal agent. Fitoterapia, v. 134, p. 340- 5, 2019. FUERTES, C. M.; PACCO, G. A.; DEXTRE, R. Q.; CRUZ, C. A. Y. Actividad inhibitoria in vitro de extractos etanólicos de plantas del género Annona y Piper sobre promastigotes de Leishmania braziliensis. Revista Peruana de Medicina Integrativa v. 3, p. 112-117, 2018. GAD, S. C.; PHAM, T. Safrole. In: Philip Wexler. Encyclopedia of Toxicology. Academic Press, v. 4, p. 205-207, 2014. GIOLO, M. P.; SVIDZINSKI, T. I. E. Fisiopatogenia, epidemiologia e diagnóstico laboratorial de candidemia. Jornal Brasileiro de Patologia e Medicina Laboratorial, v. 46, p. 225-234, 2010. GOBBO-NETO, L., LOPES N.P. Plantas medicinais: fatores de influência no conteúdo de metabólitos secundários. Quimica Nova 30, 374-81, 2007. GONÇALVES, R.; AYRES, V. F. S.; CARVALHO, C. E.; SOUZA, M. G. M.; GUIMARÃES, A. C.; CORRÊA, G. M.; MARTINS, C. H. G.; TAKEARA, R.; SILVA, E. O.; CROTTI, A. E. M. Chemical composition and antibacterial activity of the essential oil of Vitex agnus-castus L. (Lamiaceae). Anais da Academia Brasileira de Ciências, v. 89, p. 2825-2832, 2017. GONÇALVES, R.; AYRES, V. F. S.; MAGALHÃES, L. G.; CROTTI, A. E. M.; CORRÊA, G. M.; GUIMARÃES, A. C.; TAKEARA, R. Chemical Composition and Schistosomicidal Activity of Essential Oil of Two Piper Species from the Amazon Region. Journal of essential Oil Bearing Plantsn, v. 21, p. 811-820, 2019. GOTTLIEB, O. R.; KOKETSU, M.; MAGALHÃES, M. T.; MAIA, G. S.; MENDES, P. H.; ROCHA, A. I.; SILVA, M. L.; WILBERG, V. C. Óleos essenciais da Amazônia VII. Acta Amazonica, v. 11, p. 143-148, 1981. 42 GUIMARÃES, A. C. Estudo químico e biológico de Cladocolea micranta (Loranthaceae), uma planta medicinal da região Amazônica. Tese de Doutorado em Ciências. Núcleo de Pesquisa em Produtos Naturais. Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil, p. 305, 2005. GUIMARÃES, E.F.; CARVALHO-SILVA, M.; MONTEIRO, D. & MEDEIROS, E. Piperaceae. In: Lista de espécies da flora do Brasil. Jardim Botânico do Rio de Janeiro, 2015. Disponível em <http://floradobrasil.jbrj. gov.br/jabot/floradobrasil/FB190>. Acesso em 26 de maio de 2020. HASTUTI, U. S.; UMMAH, Y.P. I.; KHASANAH, H. N. Antifungal activity of Piper aduncum and Peperomia pellucida leaf ethanol extract against Candida albicans. AIP Conference Proceedings, v. 10, p. 1-8, 2017. HU, S.; CHEN, X.; WANG, R. Q.; YANG, L.; BAI, X. H. Natural product applications of liquid-phase microextraction. Natural product applications of liquid-phase microextraction. Trends in Analytical Chemistry, v. 113, p. 340-350, 2019. JARAMILLO-COLORADO, B. E.; PINO-BENITEZ, N.; GONZÁLEZ-COLOMA, A. Volatile composition and biocidal (antifeedant and phytotoxic activity) of the essential oils of four Piperaceae species from Choco-Colombia. Industrial Crops, v. 138, p. 3- 6, 2019. JUGREET, B. S.; SUROOWAN, S.; RENGASAMY, K. R. R.; MAHOMOODALLY, M. F. Chemistry, bioactivities, mode of action and industrial applications of Essential Oils. Trends in Food Science & Technology, 2020. KALAIARASI, V.; JOHNSON, M.; JANAKIRAMAN, N.; SIVARAMAN, A. Phytochemical and Antibacterial Studies on Peperomia Pellucida (L.) H.B.K. International Journal of Pharmaceutical Science and Research, v. 1, p. 04-06, 2016. KAYYAT, S. A.; AL-ZAHRANI, S. H. Thermal, photosynthesis and antibacterial studies of bioactive safrole derivate as precursor for natural flavor and fragrance. Arabian Journal of Chemistry, v. 7, p. 1-6, 2014. KHAN, R. A. Natural Products chemistry: The emerging trends and prospective goals. Saudi Pharmaceutical Journal, v. 26, p. 739-753, 2018. LAHLOU, M. Screening of natural products for drug discovery. Expert Opinion, v. 2, p. 697-705, 2007. LAHLOU, M. The Sucesso of Natural Products in Drug Discovery. Pharmacology & Pharmacy, v. 4, p. 17-31, 2013. LEAL, A. L. A. B.; BEZERRA, C. F.; ROCHA, J. E.; SANTOS, A. T. L.; CRUZ, R. P.; CARNEIRO, J. N. P.; SALES, D. L.; FREITAS, T. S.; TINTINO, S. R.; ALMEIDA, W. O.; AMARAL, W.; SILVA, L. E.; FERRIANI, A. P.; MAIA, B. H. L. N. S.; MORAIS- BRAGA, M. F. B.; BARRETO, H. M.; COUTINHO, H. D. M. Piper cernuum Vell.: 43 Chemical profile and antimicrobial potential evaluation. Industrial Crops & Products, v. 140, p. 1-9, 2019. LI, Y.; YANG, L.; FU, J.; YAN, M.; CHEN, D.; ZHANG, L. Microbial pathogenic and virulence mediatd by integrons on Gram-positive. Microbial pathogenesis, v. 111, p. 481-486, 2017. LINHARES, I.; RAPOSO, T.; RODRIGUES, A.; ALMEIDA, A. Incidence and Diversity of Antimicrobial Multidrug Resistance Profiles of Uropathogenic Bacteria. Biomed Research International, v. 2015, p. 1-11, 2015. MACEDO, A. L.; SILVA, D. P. D.; MOREIRA, D. L.; QUEIROZ, L. N.; VASCONCELOS, T. R. A.; ARAUJO, G. F.; KAPLAN, M. A. C.; PEREIRA, S. S. C.; ALMEIDA, E. C. P.; VALVERDE, A. L.; ROBBS, B. K. Citotoxicity and selectiveness of Brasilian Piper species toward oral carcinoma cells. Biomedicine & Pharmacotherapy, v. 110, p. 342-352, 2019. MACHADO, B. F. M. T.; FERNANDES JUNIOR, A. Óleos essenciais: aspectos gerais e usos em terapias naturais. Cadernos Acadêmicos, Tubarão, v. 3, p. 105- 127, 2011. MAJOLO, C.; MONTEIRO, P. C.; NASCIMENTO, A. V. P.; CHAVES, F. C. M.; GAMA, P. E.; BIZZO, H. R.; CHAGAS, E. C. Essential Oils from Brazilian Piper Species as Antimicrobials Against Strains of Aeromonas hydrophila. Journal of Essential Oil Bearing Plants, v. 22, p. 746-761, 2019. MANANDHAR, S.; LUITEL, S.; DAHAL, R. K. In vitro antimicrobial activity of some medicinal plants against human pathogenic bacteria. Journal of Tropical Medicine, v. 2019, p. 1-5, 2019. MANILAL, A.; SHEWANGIZAW, M.; MAMA, M.; GEZMU, T.; MERDEKIOS, B. Methicillin-Resistant Staphylococcus aureus colonization in HIV patients of Arba Minch Province, Ethiopia: Carriage rates, antibiotic resistance, and biofilm formation. Acta Microbiologica et Immunologica Hungarica, v. 66, p. 469-43, 2019. MASOMI, F.; HASSANSHAHIAN, M. Antimicrobial Activity of Five Medicinal Plants on Candida albicans. Iranian Journal of Toxicology, v. 10, p. 39-43, 2016. MICKYMARAY, S. Efficacy and mechanism of traditional medicinal plants and bioctive compounds against clinically important pathogens. Antibiotics, v. 8, p. 1-57, 2019. MATOS, F. J. A. Introdução à fitoquímica experimental. 3 ed. - Fortaleza: Edições UFC, 150 p., 2009. MOLONEY, M. G. Natural Products as a Source for Novel Antibiotics. Trends in Pharmacological Sciences, v. 37, p. 689-701, 2016. VAZ, A B.; MOTA, R. C.; BOMFIM, M. R.; VIEIRA, M. L.; ZANI, C. L.; ROSA, C. A.; ROSA, L. H. Antimicrobial activity of endophytic fungi associated with Orchidaceae in Brazil. Canadian Journal of Microbiology, v. 55(12) p. 1381-1391, 2009. 44 NASCIMENTO, P. L.; NASCIMENTO, T. C. E. S.; GOMES, J. E. G.; SILVA, M. D. S.; SOUZA, S. A.; SILVA, T. M. S.; FALCÃO, R. A.; MOREIRA, K. A. Antioxidant and antimicrobial properties of ethanolic extract od Libidibia ferrea pods. Revista Fitos, v. 9, p. 161-252, 2015. NOUMI E, MERGHNI A, M ALRESHIDI M, HADDAD, O.; AKMADAR, G.; MARTINO, L.; MASTOURI, M.; CEYLAN, O.; SNOUSSI, M.; AL-SIENI, A.; FEO, V. Chromobacterium violaceum and Pseudomonas aeruginosa PAO1: Models for Evaluating Anti-Quorum Sensing Activity of Melaleuca alternifolia Essential Oil and Its Main Component Terpinen-4-ol. Molecules, v. 23, p. 1-116, 2018. OLIVEIRA, S. S.; HANADA, R. E.; CHAVES, F. C. M.; NASCIMENTO, G. O.; ASSIS, L. A. G.; OLIVEIRA, S. S.; OLIVEIRA, M. R. Fungitoxicidade de óleos essenciais de Piper spp. sobre Colletotrichum theobromicola. Diversidade Microbiana da Amazônia, v. 3, p. 29-33, 2019. PAIXÃO, L. A.; CASTRO, F. F. S. A colonização da microbiota intestinal e sua influência na saúde do hospedeiro. Universitas: Ciências da Saúde, v. 14, p. 85- 96, 2016. PARMAR, V. S.; JAIN S. C.; BISHT, K. S.; JAIN, R.; TANEJA, P.; JHA, A.; TYAGI O. D.; PRASAD, A. K.; WENGEL, J.; OLSEN, C. E.; BOLL, P. M. Phytochemistry of the genus Piper. Phytochemistry, v. 46, 597-673, 1997. PATEL, A.; JEYASEKARAN, G.; JEYASHAKILA, R.; ANAND, T.; WILWET, PATHAK, N.; MALINI, A. H.; NEETHISELVAN, N. Prevalence of antibiotic resistant Salmonella spp. Strins in shrimp farm source waters of Nagapattian region in South India. Marine Pollution Bulletin, v. 155, p. 1-14, 2020. PATIL, R. S.; HARALE, P. M.; SHIVANGEKAR, K. V.; KUMBHAR, P. P.; DESAI, R. R. Phytochemical potential and in vitro antimicrobial activity pf Piper betle Linn. Leaf extracts. Journal of Chemical and Pharmaceutical Research, v. 7, p. 1095-1101, 2015. PATWARDHAN, B.; VAIDYA, A. D. B.; CHORGHADE, M. Ayurveda and natural products drug discovery. Current Science, v. 86, p. 789-799, 2004. PELEG, A. Y.; HOOPER, D. C. Hospital-acquired infections due to gram-negative bacteria. New England Journal of Medicine, v. 362, p. 1804-13, 2010. PINHEIRO, B. G.; SILVA, A. S. B.; SOUZA, G. E. P.; FIGUEIREDO, J. G.; CUNHA, F. Q.; LAHLOU, S.; SILVA, J. K. R.; MAIA, SOUSA, P. J. C. Chemical composition, antinociceptive and anti-inflamatory effects in rodents of the essential oil of Peperomia serpens (Sw.) Loud. Journal of Ethnopharmacology, v. 138, p. 479- 486, 2011. POOLMAN, J. T. Escherichia coli. In: QUAH, S. R. International Encyclopedia of Public Health 2 nd edition. Academic Press, v. 2 p.585-593, 2017. 45 QUÍLEZ, A.; BERENGUER, B.; GILARDONI, G.; SOUCCAR, C.; MENDONÇA, S.; OLIVEIRA, L. F. S.; MARTÍN-CALERO, M. J.; VIDARI, G. Anti-secretory, anti- inflammatory and anti-Helicobacter pylori activities of several fractions isolated from Piper carpunya Ruiz & Pav. Journal of Ethnopharmacology, v. 128, p. 538-589, 2010. RAGHAVENDRA, H. L.; PRASHITH, K. T. R. Ethnobotanical uses, phytochemistry and pharmacological activities of Peperomia pellucida (L.) Kunth (Piperaceae) - A Review. International Journal of Pharmacy and Pharmaceutical Sciences, v. 10, p. 1-8, 2018. RAKHOLIYA, K. D.; KANERIA, M. J.; CHANDA, S. V. Medicinal plants as alternative sources of therapeutics against multidrug-resistant pathogenic microorganisms based on their antimicrobial potential and synergistic properties. In: RAI, M. K.; KON, K. V. Fighting Multidrug Resistance Witch Herbal Extracts, Essentials Oils and Their Components. Academic Press, v. 1, p. 165-179, 2013. RAPADO, L. N.; NAKANO, E; OHLWEILER, F. P.; KATO, M. J.; YAMAGUCHI, L. F.; PEREIRA, C. A. B.; KAWANO, T. Molluscicidal and ovicidal activities of plant extracts of the Piperaceae on Niomphalaria glabrata (Say, 1818). Journal of Helminthology, 85, 66-72, 2011. RHAMAN, S. F. S. A.; SIJAM, K.; OMAR, D. Antibacterial activity of the crude extract of Piper sarmentosum against Pseudomonas fuscovaginae. International Journal of Applied Biology and Pharmaceutical Technology, v. 7, p. 67-72, 2016. RODRÍGUEZ, N.; RODRÍGUEZ, M. CALDERÓN, A. I.; FELICIANO, A. S.; SOLÍS, P. B.; GUPTA, M. P. Anesthetic activity of pipercallosine isolated from Piper darienense. Revista Latinoamericana de Química, v. 33, p. 115-120, 2005. ROSA, L.H.; MACHADO, K.M.; JACOB, C.C.; CAPELARI, M.; ROSA, C. A.; ZANI, C.L. Screening of Brazilian basidiomycetes for antimicrobial activity. Mem Inst Oswaldo Cruz, v. 98(7), p. 967-74, 2003. SALEHI, B.; ZAKARIA, Z. A.; GYAWALI, R.; IBRAHIN, S. A.; RAJKOVIC, J.; SHINWARI, Z. C.; KHAN, T.; SHARIFI-RAD, J.; OZLEYEN, A.; TURKDONMEZ, E.; VALUSSI, M.; TUMER, T. B.; FIDALGO, L. M.; MARTORELL, M.; SETZER, W. N. Piper species: A comprehensive review on their phytochemistry, biological activities and applications. Molecules, v. 24, p. 1-117, 2019. SAMAIN, M. S.; VRIDAGHS, A.; HESSE, M.; GOETGHEBEUR, P.; RODRÍGUEZ, F. J.; STOLL, A.; NEINHUIS C.; WANKE, S. Verhuellia is a segregate lineage in Piperaceae: more evidence from flower, fruit and pollen morphology, anatomy and development. Annals of Botany, v. 105, p. 677-688, 2010. SANTOS, M. R. A.; LIMA, R. A.; SILVA, A. G.; TEIXEIRA, C. A. D.; ALPIREZ, P. P. V.; FACUNDO, V. A. Composição química e atividade inseticida do extrato acetônico de Piper alatabaccum Trel & Yuncker (Piperaceae) sobre Hypothenemus hampei Ferrari. Revista Brasileira de Plantas Medicinais, v. 15, p. 332-336, 2013. 46 SAVANT, C.; VENKATESH.; MANNASAHEB, B. A.; JOSHI, H. Importance of Antimicrobial Agents from Plants in Present Scenario: A Review. International Journal of Pharmacology, v. 1, p. 472-484, 2014. SHAN, L.; LIU, Z.; CI, L.; SHUAI, C.; LV, X.; LI, J. Research progress on the anti- hepatic fibrosis action and mechanism of natural products. International Immunopharmacology, v. 75, p. 1-12, 2019. SHIVAKUMAR, S. N.; HIMA, B. K. Phytochemistry and pharmacological potentiality of betelvine (Piper betle L.): Review article. Journal of Pharmacognosy and Phytochemistry, v. 7, p. 213-215, 2018. SILVA, D. R.; BARONI, S.; SVIDZINSKI, A. E.; BERSANI-AMADO, C. A.; CORTEZ, D. A. G. Anti-inflamatory activity of the extract, fractions and amides from the leaves of Piper ovatum Vahl (Piperaceae). Ethnopharmacology, v. 116, p. 569-573, 2008. SILVA, M. F. R.; BEZERRA-SILVA, P. C.; LIRA, C. S.; ALBUQUERQUE, B. N. L.; AGRA NETO, A. C.; PONTUAL, E. V.; MACIEL, J. R.; PONTUAL, E. V.; MACIEL, J. R.; PAIVA, P. M. G. P.; NAVARRO, D. M. A. F. Composition and biological activities of the essential oil of Piper corcovadensis (Miq.) C. DC (Piperaceae). Experimental Parasitology, v. 165, p. 64-70, 2016. SILVA, R. J. F.; AGUIAR-DIAS A. C. A.; FAIAL, K. C. F.; MENDONÇA, M. S. Morphoanatomical and physicochemical profile of Piper callosum: valuable assessment. Brazilian Journal of Pharmacognosy, 27, 20-33, 2017. SIMÕES, C. M. O.; SPITZER VOLKER. Óleos voláteis. In: SHENKEL, E. P.; GOSMANN, G.; MELLO, J. C. P.; V. MENTS, L. A.; PETROVICK, P. R.; SIMÕES, C. M. O. Farmacognosia: da planta ao medicamento. - 6. ed.- Porto Alegre: Editora da UFRGS; Florianópolis: Editora da UFSC; p. 467-495, 2007. SOUTO, R. N. P.; HARADA, A. Y.; ANDRADE, E. H. A.; MAIA, J. G. S. Insecticidal Activity of Piper Essential Oils from the Amazon Against the Fire Ant Solenopsis saevissima (Smith) (Hymenoptera; Formicidae). Neotropical Entomology, v. 41, p. 510-517, 2012. Takeara, R.; Gonçalves, R.; Ayres, V. F. S. and Guimarães, A.C. Biological properties of essential oils from the Piper species of Brazil: a review. In: EL- SHEMY H. A. Aromatic and Medicinal Plants. Back to Nature. Publish: In Tech. p. 81-93, 2017. TONG, S. Y. C.; DAVIS, J. S.; ELCHENBERGER, E.; HOLLAND, T. L.; FOWLER JR, V. G. Stahylococcus aureus infections: Epidemiology, pathophysiology, clinical manifestations, and management. Clinical Microbiology Reviews, v. 28, p. 603- 661, 2015. VILLAMIZAR, L. H.; CARDOSO, M. G.; ANDRADE, J. TEIXEIRA, M. L.; SOARES, M. J. Linalool, a Piper aduncum essential oil component, has selective activity against Trypanosoma cruzi trypomastigote forms at 4º C. Memórias do Instituto Oswaldo Cruz, v. 112, p. 131-139, 2017. 47 VORIS, D. G. R.; DIAS, L. S.; LIMA, J. A.; LIMA, K. S. C.; LIMA, J. B. P.; LIMA, A. L. S. Evaluation of larvicidal, adulticidal, and antcholinesterase activities of essential oils of Illicium verum Hook. F., Pimenta dioica (L.) Merr., and Myristica fragrans Houtt. against Zika vírus vectors. Enviromental Science and Pollution Research, v. 25, p. 22541-22551, 2018. VYAS, M.; SHARMA, M. K.; CHOUHAN, Y. S.; GOSWAMI, C. S. Phytochemical investigation and antimicrobial activity of plant constituents of Piper betle leafs. International Journal of Chemical Studies, v. 5, p. 373-377, 2017. YIN, B.; FANG, D. M.; ZHOU, X. L.; GAO, F. Natural products as important tyrosine kinase inhibitors. European Journal of Medicinal Chemistry, v. 182, p. 1-16, 2019. Yuncker, T.G. The Piperaceae of Brazil. I-Piper-Group I, II, III, IV. Hoehnea 2,19– 366, 1972. ZAIDI, K. U.; MANI, A.; PARMAR, R.; THAWANI, V. Antifungal susceptibility pattern of Candida albicans in human infections. Open Biological Sciences Journal, v. 4. p. 1-6, 2018.pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectPiper callosumpt_BR
dc.subjectPiperaceaept_BR
dc.subjectÓleos essenciaispt_BR
dc.subjectExtratopt_BR
dc.subjectAtividade Antimicrobianapt_BR
dc.subject.cnpqCIÊNCIAS DA SAÚDE: FARMÁCIApt_BR
dc.titleCaracterização química e atividade antimicrobiana do óleo essencial, extrato bruto e frações de Piper callosum Ruiz & Pav. (Piperaceae)pt_BR
dc.typeTrabalho de Conclusão de Cursopt_BR
dc.creator.affiliationUniversidade Federal do Amazonaspt_BR
dc.date.event2021-06-17-
dc.publisher.localpubItacoatiara/AMpt_BR
dc.subject.controladoÓleo elétricopt_BR
dc.subject.controladoAção antimicrobianapt_BR
dc.subject.controladoRepelente naturalpt_BR
dc.subject.controladoEssências e óleos essenciaispt_BR
dc.creator.orcid4910312424146742pt_BR
dc.contributor.advisor1orcidhttps://orcid.org/0000-0003-1052-1822pt_BR
dc.contributor.advisor1orcidhttps://orcid.org/0000-0003-1052-1822pt_BR
dc.contributor.referee1orcidhttps://orcid.org/0000-0002-9458-8305pt_BR
dc.contributor.referee1orcidhttps://orcid.org/0000-0002-9458-8305pt_BR
dc.contributor.referee2orcidhttps://orcid.org/0000-0002-9744-3283pt_BR
dc.creator.affiliation-initUFAMpt_BR
dc.publisher.courseFarmácia - Bacharelado - Itacoatiarapt_BR
Aparece nas coleções:Trabalho de Conclusão de Curso - Graduação - Ciências da Saúde

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