Avaliação do mercado nacional dos óleos essenciais provenientes da flora brasileira e medicamentos mais comercializados no Brasil contendo estes como insumo farmacêutico ativo

Abstract

There is a growing demand for essential oils (EOs) driven by the preference for natural additives in foods and beverages, as well as increased use in aromatherapy. EOs are products obtained from a natural raw material of plant origin, by steam distillation, mechanical distillation, citrus fruit epicarp processes or by dry distillation, after separation from the aqueous phase – if any – by physical processes. Pharmacologically, EOs can have numerous properties, including antiseptic, carminative, stomachic, expectorant, anxiolytic and their main constituents are terpenes and phenylpropanoids. Therefore, this work proposes to evaluate the national market for essential oils from Brazilian flora and medicines most sold in Brazil containing them as an active pharmaceutical ingredient. For these objectives, a bibliographic review was carried out using the PubMed, Mendeley and Google Scholar databases, with interest in publications between the years 2018 and 2024. The registered medicines were searched in the database of the National Health Surveillance Agency (ANVISA) and for checking potential new products and innovations with these inputs was consulted with the National Institute of Industrial Property (INPI). The species that presented records of EO production are: pitangueira (Eugenia uniflora), pink pepper (Schinus terebunthifolius), rosemary (Baccharis dracunculifolia), baleeira herb (Cordia verbenaceae) and rosin (Protium heptaphyllum). Of the species mentioned, only baleeira herb is registered as a medicine by ANVISA, Acheflan, which can be presented as a cream or spray, and Cordiaflan, in an ointment pharmaceutical form. They are recommended mainly for their anti-inflammatory and analgesic properties. The INPI and GOOGLE patent database returned 29 results of technological innovations using OE, 20 of which were initiated by public institutions, which stand out as research and development centers.